Sad there isn't much discussion of this series here. FYI, this is a remake of the 1969 anime series, which itself is based on a manga by Osamu Tezuka (Astro Boy). Dororo was also the first entry of the Masterpiece Theater series of anime adaptations of classical works like Anne of Green Gables and The Sound of Music. A videogame titled "Blood Will Tell", which is based on Dororo, was released for the Playstation 2 in the US and Japan.
The story of Dororo is loosely set during the early period of the Sengoku Jidai, more specifically the Kaga Rebellion, as the series is set in Kaga province. The land of which the Daigo clan controls is what will be modern-day Ishikawa District.